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Best Heartworm Prevention Medicines for Dogs

Understanding Heartworm Disease and Prevention Heartworm disease is a life-threatening condition caused by parasitic worms in a dog’s heart, lungs, and arteries. These worms are transmitted to dogs through mosquito bites and can lead to heart failure if left untreated. As a responsible pet owner, starting treatment promptly upon diagnosis and maintaining year-round heartworm prevention is crucial.

The Importance of Year-Round Heartworm Prevention

 Year-round prevention is essential for all dogs, regardless of their climate. Mosquitoes carrying heartworm larvae or adult worms can still infect your dog, even in colder climates. Consistent use of a monthly chewable tablet or topical solution can eliminate existing adult worms and prevent new ones from developing. You can consult your vet about additional preventative measures if you live in an area with known heartworm infections.

Best Heartworm Preventatives for Dogs

 There are three main types of heartworm preventatives: oral medications, topical medications, and injectable medications. Choosing the best heartworm prevention medicine for your dog depends on age, lifestyle, and your vet’s recommendations.

Oral Heartworm Preventatives

  1. Simparica Trio
  2. Nexgard Plus
  3. Heartgard Plus
  4. Interceptor Plus
  5. Sentinel Spectrum
  6. Tri-Heart Plus
  7. Trifexis

Oral heartworm preventatives are typically administered monthly and are suitable for dogs over six weeks old. These medicines often contain active ingredients like ivermectin, moxidectin, milbemycin oxime, or pyrantel to effectively prevent heartworms and other intestinal worms.

We recommend Simparica Trio for most pets to protect against heartworm disease, intestinal parasites, and external parasites.

Topical Heartworm Preventatives

  1. Revolution
  2. Advantage Multi

Topical heartworm preventatives are applied to the skin between the shoulder blades, protecting against heartworms, fleas, and ticks. These treatments are generally given once a month and are suitable for dogs and puppies over six weeks of age.

Injectable Heartworm Preventatives

  1. ProHeart 6
  2. ProHeart 12

Injectable heartworm preventatives (containing moxidectin) offer an alternative to oral and topical treatments. ProHeart 6, for example, can be used in puppies as young 6 months of age, while ProHeart 12 is suitable for dogs over one year of age. These injections protect for six or 12 months, depending on the chosen product. These injections also protect against hookworm intestinal parasites.

Choosing the Right Heartworm Preventative for Your Dog 

Please consult your veterinarian to find the best possible heartworm prevention method for your dog’s lifestyle and budget. If heartworm disease is prevalent in your area, using a product specifically targeting heartworms is vital. A monthly chewable tablet might be a more convenient option over topical applications, as it doesn’t require a messy application.

Common Side Effects of Heartworm Preventatives

  1. Vomiting
  2. Diarrhea
  3. Loss of appetite


To keep your dog healthy, ensure they are on a heartworm preventive recommended by your vet. Year-round heartworm prevention is crucial, so follow the recommended treatment schedule to protect your pet from this dangerous disease.

Disclaimer: The information provided on this veterinary website is intended for general educational purposes only and should not be considered as a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a licensed veterinarian for any concerns or questions regarding the health and well-being of your pet. This website does not claim to cover every possible situation or provide exhaustive knowledge on the subjects presented. The owners and contributors of this website are not responsible for any harm or loss that may result from the use or misuse of the information provided herein.

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